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Number of Immunosuppression-related Genes : 995

Number of Diseases : 260

HisgAtlas is a manual curation database for human immunosuppression genes. Immunosuppression is body’s state in which the activation or efficacy of immune system is weakened. It is associated with a wide spectrum of human diseases, such as autoimmune diseases, allergy, organ transplantation rejection and chronic infectious diseases. In the last two decades, tremendous efforts have been made to elucidate the mechanism of hundreds of immunosuppression genes. For example, The programmed cell death-1 (PD-1) receptor, a cell surface receptor on T cells,which plays a critical role in peripheral tolerance, can also compromise antiviral and antitumor T cell responses through the inhibition of T cell proliferation. Blockade of the PD-1/PD-L1 pathway can active antitumor immune responses and have been a very successful therapy for cancer. Immunosuppression genes could be valuable drug targets or biomarkers for the immunotherapeutic treatment of different diseases. However, the information of all previously identified immunosuppression genes is dispersed in thousands of publications. Here we provided the HisgAtlas database that collects 995 previously identified human immunosuppression genes using text mining and manual curation.

Reference

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2. Chatenoud, L. (2014). Teaching the immune system “self” respect and tolerance. Science, 344, 1343-1344.

3. Pardoll, D. M. (2012). The blockade of immune checkpoints in cancer immunotherapy. Nature Reviews Cancer, 12, 252-264.

4. Morelli, A. E., & Thomson, A. W. (2007). Tolerogenic dendritic cells and the quest for transplant tolerance. Nature Reviews Immunology, 7, 610-621.

5. Pan, P. Y., Ozao, J., Zhou, Z., et al. (2008). Advancements in immune tolerance. Advanced drug delivery reviews, 60, 91-105.