Search AAgAtlas
E.g. BRCA1
E.g. Breast carcinoma
Introduction

Autoantibodies are antibodies that are produced by the B-cell immune system against an individual’s own antigens and play pivotal roles in the maintenance of healthy individuals’ homeostasis, as well as in tumors and autoimmune diseases. In the last two decades, tremendous efforts have been devoted to elucidate the generation, evolution and function of autoantibodies and their targets, autoantigens [1-9]. However, the previously identified autoantigens are randomly dispersed in the literature. Here we present a database containing 1,126 well-annotated autoantigens, determined by text-mining and manual curation [10]. AAgAtlas database 1.0 provides a user-friendly interface to conveniently browse, retrieve and download the list of autoantigens and their associated diseases. This database is freely accessible at http://biokb.ncpsb.org/aagatlas.

Publication: Dan Wang#, Liuhui Yang, Ping Zhang, Joshua LaBaer, Henning Hermjakob*, Dong Li* and Xiaobo Yu*. AAgAtlas 1.0: a human autoantigen database. Nucl. Acids Res.2017. 45 (D1): D769-D776

References

1.Plotz PH. The autoantibody repertoire: searching for order. Nat Rev Immunol. 2003 3(1):73-8.

2.Elkon K, Casali P. Nature and functions of autoantibodies. Nat Clin Pract Rheumatol. 2008 4(9):491-8.

3.Madi A, Hecht I, Bransburg-Zabary S, et al. Organization of the autoantibody repertoire in healthy newborns and adults revealed by system level informatics of antigen microarray data. Proc Natl Acad Sci U S A. 2009 106(34):14484-9.

4.Anderson KS, LaBaer J. The sentinel within: exploiting the immune system for cancer biomarkers. J Proteome Res. 2005 4(4):1123-33.

5.Olsen NJ, Karp DR. Autoantibodies and SLE—the threshold for disease. Nat Rev Rheumatol. 2014 10(3):181-6.

6.Wang X, Yu J, Sreekumar A, Varambally S, et al. Autoantibody signatures in prostate cancer. N Engl J Med. 2005 353(12):1224-35.

7.Wang J, Figueroa JD, Wallstrom G, et al. Plasma Autoantibodies Associated with Basal-like Breast Cancers. Cancer Epidemiol Biomarkers Prev. 2015 24(9):1332-40.

8.Mellman I, Coukos G, Dranoff G. Cancer immunotherapy comes of age. Nature. 2011 480(7378):480-9.

9.Jackson HJ, Rafiq S, Brentjens RJ, Driving CAR T-cells forward. Nat Rev Clin Oncol. 2016 13(6):370-83.

10.Nunes T, Campos D, Matos S, et al. BeCAS: biomedical concept recognition services and visualization. Bioinformatics, 2013, 29(15): 1915-1916.


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