OsteoporosAtlas is a manually curated database for human osteoporosis-related genes. Osteoporosis is a common disorder with a strong genetic component characterized by reduced bone mass and increased risk of fragility fractures. Hundreds of osteoporosis-related genes have been identified in thousands of publications, which involve in the pathogenesis of individual cases, novel diagnostic and prognostic biomarker, individual treatment responses and precision medicine. Here we present a database containing 617 osteoporosis-related encoding genes, 131 microRNAs, determined by text-mining and manual curation.

E.g. SOST
E.g. Wnt Signaling Pathway
E.g. hsa-miR-21
Search by Protein Sequence(example)
Search by Nucleotide Sequence(example)

1. Zajickova, Katerina, and I. Zofkova. "Osteoporosis: genetic analysis of multifactorial disease." Endocrine regulations 37.1 (2003): 31-44.

2. Eisman, John A. "Genetics of osteoporosis." Endocrine reviews 20.6 (1999): 788-804.

3. Richards, J. Brent, Hou-Feng Zheng, and Tim D. Spector. "Genetics of osteoporosis from genome-wide association studies: advances and challenges." Nature Reviews Genetics 13.8 (2012): 576.

4. Grant, Struan FA, et al. "Reduced bone density and osteoporosis associated with a polymorphic Sp1 binding site in the collagen type I α 1 gene." Nature genetics 14.2 (1996): 203.

5. Krzeszinski, Jing Y., et al. "miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2." Nature 512.7515 (2014): 431.

Number of Osteoporosis-related encoding Genes : 617

Drug targets in encoding Gene : 51

Biomarkers in encoding Genes : 10

Number of microRNAs : 131

Biomarkers in microRNAs : 24

Drug targets in microRNAs : 43

CRAFT 2.0 corpus was used to test the performance of our bio-entity recognizer. the precision, recall and F-measure of our bio-entity recognizer for identifying gene/protein were 0.959, 0.802 and 0.874 respectively.

See FAQ-4.(2) for more detailed information about testing process.

CRAFT 2.0-independent test result