Notice (08/04/2020):
Owing to the domain name change of our research center, UVGD will be moved to new url: Please simultaneously try both urls. Sorry for the inconvenience!

E.g. XPC
E.g. Xeroderma pigmentosum
E.g. DNA repair
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   UVGD is a manual curation database for ultraviolet-related genes. Exposing to ultraviolet for a certain time always triggers some significant molecular effects in organisms. Hundreds of genes have been identified to be responsible for the molecular biology effect of ultraviolet radiation. In the current version of UVGD, there are 663 ultraviolet-related genes collected by literature-mining and manual curation.

Citation: Hao Xu, Yan Wang, Lihong Diao, Xun Wang, Yi Zhang, Jiarun Zhu, Jinying Liu, Jingwen Yao, Zhongyang Liu, Yang Li, Fuchu He, Zhidong Wang, Yuan Liu & Dong Li (2019) UVGD 1.0: a gene-centric database bridging ultraviolet radiation and molecular biology effects in organisms, International Journal of Radiation Biology, 95:8, 1172-1177, DOI: 10.1080/09553002.2019.1609127

1. Rastogi, Rajesh P., et al. "Molecular mechanisms of ultraviolet radiation-induced DNA damage and repair. Journal of nucleic acids 2010 (2010).

2. Rivas, Jorge M., and Stephen E. Ullrich. "The role of IL‐4, IL‐10, and TNF‐α in the immune suppression induced by ultraviolet radiation. Journal of leukocyte biology 56.6 (1994): 769-775.

3. Ullrich, Stephen E. "Mechanism involved in the systemic suppression of antigen-presenting cell function by UV irradiation. Keratinocyte-derived IL-10 modulates antigen-presenting cell function of splenic adherent cells. The Journal of Immunology 152.7 (1994): 3410-3416.

4. Kim, Ryeo-Ok, et al. "Ultraviolet B retards growth, induces oxidative stress, and modulates DNA repair-related gene and heat shock protein gene expression in the monogonont rotifer, Brachionus sp. Aquatic Toxicology 101.3-4 (2011): 529-539.

5. Zhou, Xiwu, et al. "Heat shock transcription factor-1 regulates heat shock protein-72 expression in human keratinocytes exposed to ultraviolet B light. Journal of investigative dermatology 111.2 (1998): 194-198.

Number of UV-related Genes: 663

Number of Phenotype terms: 117

Number of Biological Process terms: 17

Number of MeSH terms: 929